Study Finds Two Blood Proteins May be the Secret to Longevity
Study Finds Two Blood Proteins May be the Secret to Longevity
Health and longevity is the common pursuit of almost everyone, even the powerful emperors in history are not exempt. Recently, in a study, scientists proved through experiments that there are two blood proteins in the human body that affect human health, and the development of drugs targeting these proteins is likely to slow down human aging.
With the increase of age, the functions of human organs will also decline, which will lead to diseases and poor health. Not only that, but related factors including heredity, lifestyle, environment, etc. also have a certain impact on the speed of human aging. In the study, researchers from the University of Edinburgh not only analyzed which proteins affect the human aging process, but also revealed these How proteins play a role in human aging.
Ultimately, of the 857 proteins studied, the researchers identified two that have a significant negative impact on the aging process in humans, The related research results were published in Nature Aging under the title "Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biologicaltargets for human aging".
In the study, researchers at the University of Edinburgh combined the results of six large genetic studies with human aging, a causal relationship between protein levels and human aging was inferred using a fully validated set of quantitative trait loci for blood proteins of 857 proteins using whole-proteomic two-sample Mendelian randomization and co-location methods.
After analysis, the researchers found that the levels of four proteins LPA, VCAM1, OLFM1 and LRP12 may have certain effects on human aging. Ultimately, they found that of these proteins, apolipoprotein A (LPA) and vascular cell adhesion factor 1 (VCAM1) had the most significant effects on aging. Overall, each unit increase in the standard deviation of LPA levels in blood means that a person may lose 7 months of life; A unit reduction in the standard deviation of VCAM1 levels in blood means a person's life may be extended by 18 months.
Apolipoprotein A (LPA) is produced in the liver and plays a corresponding role in blood coagulation. But high levels of LPA increase the risk of atherosclerosis, which can lead to diseases such as heart disease and stroke.
Another protein, vascular cell adhesion molecule 1 (VCAM1), is mainly present on the surface of endothelial cells. This protein controls the expansion and contraction of blood vessels and plays a role in coagulation and immune responses. Expression levels of this protein increase with age, and high levels of VCAM1 may contribute to the development of inflammation in blood vessels. Although there are no clinical trials involving VCAM1, mouse studies have demonstrated that anti-VCAM1 antibody treatment or inducible deletion of VCAM1 can significantly improve cognitive performance in aged mice.
And interestingly, there is a certain relationship between the above two proteins, and the increase of LAP level will increase the expression level of VCAM1.
The researchers say that because there is no genome-wide association summary data, it is impossible to accurately assess the impact of two other proteins, LRP12 and OLFM1, on human aging. LRP12 may play a role in human brain development and tumor proliferation or suppression, OLFM1 has been shown to inhibit colorectal cancer metastasis, But it was unclear whether lowering levels of these two proteins would have beneficial effects in humans.
Taken together, the researchers suggest that drugs that treat disease by lowering levels may have the added benefit of improving quality of life and prolonging life.
At present, Wuxi Donglin Sci & Tech Development Co.,Ltd. has developed Elisa products related to LPA and VCAM1, If you want to know information about Elisa kits, you can directly visit the website:
Lipoprotein, a (Lpa) ELISA Kit:
http://www.dldevelop.com/Research-reagent/dl-lpa-hu.html
Vascular Cell Adhesion Molecule 1 (VCAM1) ELISA Kit:
http://www.dldevelop.com/Research-reagent/dl-vcam1-hu.html
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Health and longevity is the common pursuit of almost everyone, even the powerful emperors in history are not exempt. Recently, in a study, scientists proved through experiments that there are two blood proteins in the human body that affect human health, and the development of drugs targeting these proteins is likely to slow down human aging.
With the increase of age, the functions of human organs will also decline, which will lead to diseases and poor health. Not only that, but related factors including heredity, lifestyle, environment, etc. also have a certain impact on the speed of human aging. In the study, researchers from the University of Edinburgh not only analyzed which proteins affect the human aging process, but also revealed these How proteins play a role in human aging.
Ultimately, of the 857 proteins studied, the researchers identified two that have a significant negative impact on the aging process in humans, The related research results were published in Nature Aging under the title "Mendelian randomization of genetically independent aging phenotypes identifies LPA and VCAM1 as biologicaltargets for human aging".
In the study, researchers at the University of Edinburgh combined the results of six large genetic studies with human aging, a causal relationship between protein levels and human aging was inferred using a fully validated set of quantitative trait loci for blood proteins of 857 proteins using whole-proteomic two-sample Mendelian randomization and co-location methods.
After analysis, the researchers found that the levels of four proteins LPA, VCAM1, OLFM1 and LRP12 may have certain effects on human aging. Ultimately, they found that of these proteins, apolipoprotein A (LPA) and vascular cell adhesion factor 1 (VCAM1) had the most significant effects on aging. Overall, each unit increase in the standard deviation of LPA levels in blood means that a person may lose 7 months of life; A unit reduction in the standard deviation of VCAM1 levels in blood means a person's life may be extended by 18 months.
Apolipoprotein A (LPA) is produced in the liver and plays a corresponding role in blood coagulation. But high levels of LPA increase the risk of atherosclerosis, which can lead to diseases such as heart disease and stroke.
Another protein, vascular cell adhesion molecule 1 (VCAM1), is mainly present on the surface of endothelial cells. This protein controls the expansion and contraction of blood vessels and plays a role in coagulation and immune responses. Expression levels of this protein increase with age, and high levels of VCAM1 may contribute to the development of inflammation in blood vessels. Although there are no clinical trials involving VCAM1, mouse studies have demonstrated that anti-VCAM1 antibody treatment or inducible deletion of VCAM1 can significantly improve cognitive performance in aged mice.
And interestingly, there is a certain relationship between the above two proteins, and the increase of LAP level will increase the expression level of VCAM1.
The researchers say that because there is no genome-wide association summary data, it is impossible to accurately assess the impact of two other proteins, LRP12 and OLFM1, on human aging. LRP12 may play a role in human brain development and tumor proliferation or suppression, OLFM1 has been shown to inhibit colorectal cancer metastasis, But it was unclear whether lowering levels of these two proteins would have beneficial effects in humans.
Taken together, the researchers suggest that drugs that treat disease by lowering levels may have the added benefit of improving quality of life and prolonging life.
At present, Wuxi Donglin Sci & Tech Development Co.,Ltd. has developed Elisa products related to LPA and VCAM1, If you want to know information about Elisa kits, you can directly visit the website:
Lipoprotein, a (Lpa) ELISA Kit:
http://www.dldevelop.com/Research-reagent/dl-lpa-hu.html
Vascular Cell Adhesion Molecule 1 (VCAM1) ELISA Kit:
http://www.dldevelop.com/Research-reagent/dl-vcam1-hu.html
http://www.dldevelop.com/Research-reagent/dl-vcam1-mu.html
http://www.dldevelop.com/Research-reagent/dl-vcam1-p.html
http://www.dldevelop.com/Research-reagent/dl-vcam1-ra.html
http://www.dldevelop.com/Research-reagent/dl-vcam1-rb.html
http://www.dldevelop.com/Research-reagent/dl-vcam1-si.html
